Genetic and Pathological Links Between Parkinson's Disease and the Lysosomal Disorder Sanfilippo Syndrome
Identifieur interne : 001109 ( Main/Exploration ); précédent : 001108; suivant : 001110Genetic and Pathological Links Between Parkinson's Disease and the Lysosomal Disorder Sanfilippo Syndrome
Auteurs : Sophie E. Winder-Rhodes [Royaume-Uni] ; Pablo Garcia-Reitböck [Royaume-Uni] ; Maria Ban [Royaume-Uni] ; Jonathan R. Evans [Royaume-Uni] ; Thomas S. Jacques [Royaume-Uni] ; Anu Kemppinen [Royaume-Uni] ; Thomas Foltynie [Royaume-Uni] ; Caroline H. Williams-Gray [Royaume-Uni] ; Patrick F. Chinnery [Royaume-Uni] ; Gavin Hudson [Royaume-Uni] ; David J. Burn [Royaume-Uni] ; Liesl M. Allcock [Royaume-Uni] ; Stephen J. Sawcer [Royaume-Uni] ; Roger A. Barker [Royaume-Uni] ; Maria Grazia Spillantini [Royaume-Uni]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background: Parkinson's disease (PD) is a common neurodegenerative disorder of unknown etiology. The characteristic α-synuclein aggregation of PD is also a feature of Sanfilippo syndrome, a storage disorder caused by α-N-acetylglucosaminidase (NAGLU) gene mutations. We explored genetic links between these disorders and studied the pathology of Sanfilippo syndrome to investigate a common pathway toward α-synuclein aggregation. Methods: We typed the 2 single-nucleotide polymorphisms that tag the common haplotypes of NAGLU in 926 PD patients and 2308 controls and also stained cortical tissue from 2 cases of Sanfilippo A syndrome using the anti-α-synuclein antibody, Per7. Results: Allelic analysis showed an association between rs2071046 and risk for PD (P 1.3 x 10-3). Intracellular α-synuclein accumulation was observed in the cortical tissue of both Sanfilippo A syndrome cases. Conclusions: This study suggests a possible role of NAGLU in susceptibility to PD while extending evidence for α-synuclein aggregation in the brain in lysosomal storage disorders. Our findings support a mechanism involving lysosomal dysfunction more generally in the pathogenesis of PD.
Affiliations:
- Royaume-Uni
- Angleterre, Angleterre de l'Est, Grand Londres
- Cambridge, Londres
- Université de Cambridge
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Burn</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>UCL Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Allcock, Liesl M" sort="Allcock, Liesl M" uniqKey="Allcock L" first="Liesl M." last="Allcock">Liesl M. Allcock</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute for Ageing and Health, Newcastle University</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Sawcer, Stephen J" sort="Sawcer, Stephen J" uniqKey="Sawcer S" first="Stephen J." last="Sawcer">Stephen J. Sawcer</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A." last="Barker">Roger A. Barker</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Grazia Spillantini, Maria" sort="Grazia Spillantini, Maria" uniqKey="Grazia Spillantini M" first="Maria" last="Grazia Spillantini">Maria Grazia Spillantini</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0113827</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0113827 INIST</idno><idno type="RBID">Pascal:12-0113827</idno><idno type="wicri:Area/PascalFrancis/Corpus">000263</idno><idno type="wicri:Area/PascalFrancis/Curation">002A51</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000182</idno><idno type="wicri:doubleKey">0885-3185:2012:Winder Rhodes S:genetic:and:pathological</idno><idno type="wicri:Area/Main/Merge">001161</idno><idno type="wicri:Area/Main/Curation">001109</idno><idno type="wicri:Area/Main/Exploration">001109</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Genetic and Pathological Links Between Parkinson's Disease and the Lysosomal Disorder Sanfilippo Syndrome</title><author><name sortKey="Winder Rhodes, Sophie E" sort="Winder Rhodes, Sophie E" uniqKey="Winder Rhodes S" first="Sophie E." last="Winder-Rhodes">Sophie E. Winder-Rhodes</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Garcia Reitbock, Pablo" sort="Garcia Reitbock, Pablo" uniqKey="Garcia Reitbock P" first="Pablo" last="Garcia-Reitböck">Pablo Garcia-Reitböck</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology, St. George's Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ban, Maria" sort="Ban, Maria" uniqKey="Ban M" first="Maria" last="Ban">Maria Ban</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Evans, Jonathan R" sort="Evans, Jonathan R" uniqKey="Evans J" first="Jonathan R." last="Evans">Jonathan R. Evans</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Jacques, Thomas S" sort="Jacques, Thomas S" uniqKey="Jacques T" first="Thomas S." last="Jacques">Thomas S. Jacques</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Neural Development Unit, UCL-Institute of Child Health & Department of Histopathology, Great Ormond Street Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kemppinen, Anu" sort="Kemppinen, Anu" uniqKey="Kemppinen A" first="Anu" last="Kemppinen">Anu Kemppinen</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Foltynie, Thomas" sort="Foltynie, Thomas" uniqKey="Foltynie T" first="Thomas" last="Foltynie">Thomas Foltynie</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>UCL Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Williams Gray, Caroline H" sort="Williams Gray, Caroline H" uniqKey="Williams Gray C" first="Caroline H." last="Williams-Gray">Caroline H. Williams-Gray</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Chinnery, Patrick F" sort="Chinnery, Patrick F" uniqKey="Chinnery P" first="Patrick F." last="Chinnery">Patrick F. Chinnery</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>UCL Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hudson, Gavin" sort="Hudson, Gavin" uniqKey="Hudson G" first="Gavin" last="Hudson">Gavin Hudson</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute for Ageing and Health, Newcastle University</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>UCL Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Allcock, Liesl M" sort="Allcock, Liesl M" uniqKey="Allcock L" first="Liesl M." last="Allcock">Liesl M. Allcock</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute for Ageing and Health, Newcastle University</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Sawcer, Stephen J" sort="Sawcer, Stephen J" uniqKey="Sawcer S" first="Stephen J." last="Sawcer">Stephen J. Sawcer</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A." last="Barker">Roger A. Barker</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Grazia Spillantini, Maria" sort="Grazia Spillantini, Maria" uniqKey="Grazia Spillantini M" first="Maria" last="Grazia Spillantini">Maria Grazia Spillantini</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Parkinson's disease (PD) is a common neurodegenerative disorder of unknown etiology. The characteristic α-synuclein aggregation of PD is also a feature of Sanfilippo syndrome, a storage disorder caused by α-N-acetylglucosaminidase (NAGLU) gene mutations. We explored genetic links between these disorders and studied the pathology of Sanfilippo syndrome to investigate a common pathway toward α-synuclein aggregation. Methods: We typed the 2 single-nucleotide polymorphisms that tag the common haplotypes of NAGLU in 926 PD patients and 2308 controls and also stained cortical tissue from 2 cases of Sanfilippo A syndrome using the anti-α-synuclein antibody, Per7. Results: Allelic analysis showed an association between rs2071046 and risk for PD (P 1.3 x 10-<sup>3</sup>). Intracellular α-synuclein accumulation was observed in the cortical tissue of both Sanfilippo A syndrome cases. Conclusions: This study suggests a possible role of NAGLU in susceptibility to PD while extending evidence for α-synuclein aggregation in the brain in lysosomal storage disorders. Our findings support a mechanism involving lysosomal dysfunction more generally in the pathogenesis of PD.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Grand Londres</li></region><settlement><li>Cambridge</li><li>Londres</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Winder Rhodes, Sophie E" sort="Winder Rhodes, Sophie E" uniqKey="Winder Rhodes S" first="Sophie E." last="Winder-Rhodes">Sophie E. Winder-Rhodes</name></region><name sortKey="Allcock, Liesl M" sort="Allcock, Liesl M" uniqKey="Allcock L" first="Liesl M." last="Allcock">Liesl M. Allcock</name><name sortKey="Ban, Maria" sort="Ban, Maria" uniqKey="Ban M" first="Maria" last="Ban">Maria Ban</name><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A." last="Barker">Roger A. Barker</name><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name><name sortKey="Chinnery, Patrick F" sort="Chinnery, Patrick F" uniqKey="Chinnery P" first="Patrick F." last="Chinnery">Patrick F. Chinnery</name><name sortKey="Evans, Jonathan R" sort="Evans, Jonathan R" uniqKey="Evans J" first="Jonathan R." last="Evans">Jonathan R. Evans</name><name sortKey="Foltynie, Thomas" sort="Foltynie, Thomas" uniqKey="Foltynie T" first="Thomas" last="Foltynie">Thomas Foltynie</name><name sortKey="Garcia Reitbock, Pablo" sort="Garcia Reitbock, Pablo" uniqKey="Garcia Reitbock P" first="Pablo" last="Garcia-Reitböck">Pablo Garcia-Reitböck</name><name sortKey="Garcia Reitbock, Pablo" sort="Garcia Reitbock, Pablo" uniqKey="Garcia Reitbock P" first="Pablo" last="Garcia-Reitböck">Pablo Garcia-Reitböck</name><name sortKey="Grazia Spillantini, Maria" sort="Grazia Spillantini, Maria" uniqKey="Grazia Spillantini M" first="Maria" last="Grazia Spillantini">Maria Grazia Spillantini</name><name sortKey="Hudson, Gavin" sort="Hudson, Gavin" uniqKey="Hudson G" first="Gavin" last="Hudson">Gavin Hudson</name><name sortKey="Jacques, Thomas S" sort="Jacques, Thomas S" uniqKey="Jacques T" first="Thomas S." last="Jacques">Thomas S. Jacques</name><name sortKey="Kemppinen, Anu" sort="Kemppinen, Anu" uniqKey="Kemppinen A" first="Anu" last="Kemppinen">Anu Kemppinen</name><name sortKey="Sawcer, Stephen J" sort="Sawcer, Stephen J" uniqKey="Sawcer S" first="Stephen J." last="Sawcer">Stephen J. Sawcer</name><name sortKey="Williams Gray, Caroline H" sort="Williams Gray, Caroline H" uniqKey="Williams Gray C" first="Caroline H." last="Williams-Gray">Caroline H. Williams-Gray</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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